Aβ-POSITIVITY PREDICTS COGNITIVE DECLINE BUT COGNITION ALSO PREDICTS PROGRESSION TO Aβ-POSITIVITY
نویسندگان
چکیده
منابع مشابه
Stress Echocardiography Positivity Predicts Cancer Death
BACKGROUND Stress echocardiography (SE) predicts cardiac death, but an increasing share of cardiac patients eventually die of cancer. The aim of the study was to assess whether SE positivity predicts cancer death. METHODS AND RESULTS In a retrospective analysis of prospectively acquired single-center, observational data, we evaluated 4673 consecutive patients who underwent SE from 1983 to 200...
متن کاملAβ(39-42) modulates Aβ oligomerization but not fibril formation.
Recently, certain C-terminal fragments (CTFs) of Aβ42 have been shown to be effective inhibitors of Aβ42 toxicity. Here, we examine the interactions between the shortest CTF in the original series, Aβ(39-42), and full-length Aβ. Mass spectrometry results indicate that Aβ(39-42) binds directly to Aβ monomers and to the n = 2, 4, and 6 oligomers. The Aβ42:Aβ(39-42) complex is further probed using...
متن کاملTime to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease
Background: Aβ pathology is associated with longitudinal changes of brain metabolism, atrophy, and cognition, in cognitively healthy elders. However, Aβ information is usually measured cross-sectionally and dichotomized to classify subjects as Aβ-positive or Aβ-negative, making it difficult to evaluate when brain and cognitive changes occur with respect to emerging Aβ pathology. In this study, ...
متن کاملThe aging positivity effect and immune function: positivity in recall predicts higher CD4 counts and lower CD4 activation.
Older adults favor emotionally positive material over emotionally negative material in information processing. Given the potentially harmful consequences of avoiding negative information, this aging positivity effect may provide benefits that offset its costs. To test this possibility, we assessed positivity in recall and blood indicators of immune function among older adults. Greater positivit...
متن کاملBRIEF REPORT The Aging Positivity Effect and Immune Function: Positivity in Recall Predicts Higher CD4 Counts and Lower CD4 Activation
Older adults favor emotionally positive material over emotionally negative material in information processing. Given the potentially harmful consequences of avoiding negative information, this aging positivity effect may provide benefits that offset its costs. To test this possibility, we assessed positivity in recall and blood indicators of immune function among older adults. Greater positivit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.06.4380